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Another study also reported that activation of Nrf2/HO-1 attenuated neuronal injury and depressive-like behaviors, although the BDNF-extracellular regulated protein kinases (ERK)1/2-cAMP-response element binding protein (CREB) axis also contributed to these neuroprotective effects (Zhang J

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[DOI] [PubMed] [Google Scholar] 41.Gold R., Kappos L., Arnold D.L., Bar-Or A., Giovannoni G., Selmaj K., Tornatore C., Sweetser M.T., Yang M., Sheikh S.I., et al